Selank is a synthetic peptide that was developed in Russia and possesses nootropic and anxiolytic properties. It is an analogue of Tuftsin, a naturally occurring immunomodulatory peptide that affects T helper cells, monoamine, IL-6, neurotransmitters, and brain-derived neurotropic factor (BDNF). Although Selank and Tuftsin are similar, Selank has four additional amino acids that enhance its metabolic stability and prolong its half-life.
Selank has been studied in clinical trials as a potential treatment for generalized anxiety disorder. According to Dr. Anastasiya Volkova from the Institute of Molecular Genetics in Russia, "Numerous clinical studies have demonstrated that Selank has potent anti-anxiety and neuroprotective effects, comparable to those of benzodiazepines, which are allosteric modulators of GABAA receptors and enhance GABA's inhibitory actions." Selank is known to reduce anxiety, improve mood, lower stress levels, and enhance memory and learning. Although low doses of Selank can be sedating, unlike benzodiazepines, Selank is not addictive and does not produce withdrawal symptoms or amnesia.
Selank may help to reduce the breakdown of natural enkephalins by inhibiting enzymes that break them down. Enkephalins are natural peptides that bind to opioid receptors, reducing the severity of pain and contributing to the stress response in humans. High levels of enkephalins are found in the adrenal glands and brain. Selank may help to reduce levels of enkephalins in the brain, blunting the stress response and its impact on memory, learning, and concentration.
The primary concern for peptide researchers today is product purity. Nord-sci guarantees our product purity by performing independent testing of our products and providing those certifications for our customers in our product descriptions.
THIS PRODUCT IS NOT INTENDED TO TREAT, CURE OR DIAGNOSE ANY CONDITION OR DISEASE AND IS NOT FOR HUMAN CONSUMPTION. ALL PRODUCTS OFFERED ARE INTENDED FOR LABORATORY RESEARCH USE ONLY.
All products are produced using lyophilization (freeze-drying), a preservation method that allows peptides to remain fully stable during shipping for approximately 3-4 months. Once a peptide has been reconstituted with bacteriostatic water, it must be refrigerated to maintain integrity. After reconstitution, peptides typically remain stable for up to 30 days when stored properly.
Lyophilization, also referred to as cryodesiccation, is a specialized dehydration process in which peptides are first frozen and then exposed to a low-pressure environment. This causes the water within the vial to transition directly from a solid to a vapor (sublimation), leaving behind a dry, crystalline white material known as a lyophilized peptide. In this powdered form, peptides may be safely stored at room temperature until they are ready to be reconstituted with bacteriostatic water.
After delivery, peptides should be protected from heat and light. If use is expected within the near future (whether days, weeks, or a few months) refrigerated storage below 4°C (39°F) is generally sufficient. Lyophilized peptides are commonly stable at room temperature for several weeks or longer, making short-term ambient storage acceptable when use is anticipated within that timeframe.
For extended storage, ranging from several months to multiple years, freezing is strongly recommended. Storage at -80°C (-112°F) offers optimal long-term stability and helps preserve peptide structure and quality over time.
For more detailed guidance on peptide handling and storage best practices, please refer to the resource below:
Selank is a research-grade synthetic heptapeptide investigated in neuroimmune modulation and behavioral neuroscience models. Developed as an analogue of the endogenous tetrapeptide tuftsin, Selank extends the parent motif with a C-terminal Pro-Gly-Pro fragment to improve stability in experimental settings. In contemporary research literature, Selank is commonly discussed in the context of stress-response signaling, monoamine regulation, and biomarker-driven study designs that evaluate cognition- and anxiety-adjacent endpoints.
Selank Research Peptide Specifications:
| Unit Size | 5 mg/vial |
| Unit Quantity | 1 vial |
| Purity (HPLC) | > 99% (see COA for lot-specific results) |
| Sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP) |
| CAS Number | 129954-34-3 |
| Appearance | Lyophilized White Powder |
| Source | Chemical Synthesis |
| Storage Conditions | Store lyophilized Selank at −20 °C or below, protected from light and moisture. Reconstituted solutions are typically refrigerated (2–8 °C) and used promptly per institutional guidelines. For general handling best practices, see Nordsci’s peptide stability guidance in the related articles below. |
| Research Use Only | This peptide is supplied exclusively for laboratory research use. Not for human consumption, clinical use, or veterinary applications. Please review all terms and conditions prior to purchase. |
Selank is positioned in the literature as a “tuftsin-derived” peptide, designed to retain immunomodulatory signaling characteristics while expanding investigational relevance to neurochemical pathways. In preclinical work, Selank has been associated with changes in monoamine metabolism and cytokine-linked signaling (including IL-6 discussions in secondary sources), and it has also been studied in models evaluating neurotrophin-related expression patterns such as brain-derived neurotrophic factor (BDNF). These themes make Selank a recurring tool compound in neuroimmune research programs that need a peptide-based variable with both immune-adjacent and brain-adjacent plausibility.
Practically, Selank is often discussed alongside other cognitive peptides such as Semax when research teams design comparative arms for cognition, motivation, or stress gating. It also appears in stacked research frameworks where investigators aim to separate “performance” outcomes from “stress interference” variables. In those designs, Selank may be included to probe whether anxiety-like behavior changes confound task performance, engagement, or habituation metrics.
Important Research Notice: Nordsci peptides are supported by independent third-party analytical testing to validate identity and purity via HPLC and mass spectrometry. A Certificate of Analysis (COA) is available for each lot to help labs align with internal quality management and documentation requirements.
THIS PRODUCT IS INTENDED FOR LABORATORY RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION. NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE OR CONDITION.
If you’re standardizing a protocol that includes cognitive peptides (for example Semax) and cellular support compounds (such as NAD), ensure your sourcing and documentation are consistent across arms. Centralizing procurement can reduce lot variance and improve auditability.
Shop all peptidesIn research discussions, Selank is frequently positioned as a variable within anxiety-like behavior paradigms and stress-response gating models. These may include elevated-plus maze–style readouts, exploration/avoidance behavior, novelty response, or task engagement metrics in standardized environments. The operational goal is typically not a “performance claim,” but rather cleaner interpretation: did an intervention shift behavior because it changed cognition, or because it reduced stress interference that suppresses engagement and learning?
Selank’s tuftsin-analogue framing keeps it relevant to neuroimmune study designs. In that context, research teams may include immune panels and inflammatory marker tracking as secondary endpoints to map correlations between immune signaling shifts and behavioral outputs. In multi-factor designs, Selank can serve as a peptide input to explore whether immune modulation coincides with measurable behavioral or neurochemical changes.
Selank has been discussed in the context of BDNF-related expression patterns in rodent models, making it a candidate variable in experiments that track plasticity-linked biomarkers alongside functional outcomes. These studies often integrate time-locked sampling (acute vs chronic exposure windows) and brain-region specificity (e.g., hippocampal sampling) to reduce noise in interpretation.
In stack-based frameworks, Selank is sometimes paired with peptides that lean more directly into alertness, motivation, or learning signals, and then balanced with cellular support agents. For example, protocols may include cognitive peptides (such as Semax) and cellular energy variables (such as NAD) while using Selank to probe whether stress gating changes influence downstream task performance. This approach can improve study interpretability by separating “capability” from “willingness to engage.”
Reconstitution Guidelines for Laboratory Use:
For laboratory work, each 5 mg vial is commonly reconstituted with an appropriate sterile diluent (often bacteriostatic water in controlled environments) to achieve the desired stock concentration. The target concentration, exposure route, and schedule should be determined by the research team based on model design, assay constraints, and institutional approvals.
Protocol Design Considerations: Selank is frequently referenced in intranasal and parenteral research discussions in public literature. Researchers should anchor any experimental framework to peer-reviewed sources, internal SOPs, and applicable ethics approvals (IACUC or equivalent). Stability discipline (aliquoting, minimizing freeze–thaw cycles, light protection, and labeling) is a material variable in peptide studies; Nordsci’s stability guide is included below for operational alignment.
Note: The information above is provided as a high-level research reference only. All experimental use must be conducted by qualified personnel in appropriately equipped facilities, following applicable regulations and institutional policies.
Each lot of Selank is supported by a Certificate of Analysis documenting peptide identity, purity, and analytical methods (HPLC, mass spectrometry, and related assays as applicable). COA documentation can be obtained for protocol files, internal quality audits, and procurement traceability.
Sourcing Selank for institutional use requires consistency: clear labeling, lot identifiers, and lot-level analytical documentation. Nordsci Peptides provides research-grade peptides with standardized handling expectations to support reproducible experimental programs.
Procurement and Compliance: Selank is sold exclusively for in vitro and preclinical research applications. It is not approved for human use. Researchers are responsible for complying with all applicable regulations and institutional policies governing peptide acquisition, storage, and study execution.
When protocols span multiple peptide inputs (cognitive, immune, and cellular energy variables), procurement fragmentation becomes a data-quality risk. Consolidate peptide sourcing and documentation to reduce avoidable variance across study arms.
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