GHRP-2 (5mg)
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GHRP-2
Specification:
| Unit Size | 5 mg/vial |
| Unit Quantity | 1 vial |
| Purity (HPLC) | 99.6% |
| Sequence | D-Alanyl-3-(naphthalen-2-yl)-D-alanyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide |
| Molecular Formula | C42H50N8O5 |
| Molecular Weight | 746.90 |
| CAS |
158861-67-7
|
| Appearance | lyophilized White Powder |
| Source | Chemical Synthesis |
| Storage | Store in an airtight container, protected from light, at a temperature of between 2-8°C. |
| Terms | The products we offer are intended for laboratory research use only. Please familiarize yourself with our terms of service prior to ordering. |
GHRP-2 is a synthetic growth hormone secretagogue that has been found to bind to the ghrelin/growth hormone secretagogue receptor. Its effects have been studied in research trials, which have shown that it can improve muscle growth, regulate the immune system, and enhance sleep cycles.
Additionally, GHRP-2 has been found to be orally bio-active, and is used as a test peptide for assessing growth hormone deficiency and secondary adrenal failure. Studies have investigated GHRP-2 in clinical trials for short stature, and ongoing research is exploring its effects on appetite, muscle growth, the immune system, and sleep cycles.
GHRP-2 can stimulate muscle growth by increasing protein deposition and reducing protein degradation, which overcomes growth plateaus that may occur due to factors such as food deprivation, disease, and adverse environmental conditions.
Moreover, GHRP-2 can prevent muscle atrophy by inactivating proteins that control the muscle degradation pathway. GHRP-2 also activates growth hormone and insulin-like growth factor-1 to promote muscle protein deposition, and encourages the development of lean body mass even in challenging conditions.
Additionally, research has shown that GHRP-2 and related peptides can protect heart cells by reducing programmed cell death, and may have specific receptors that can be targeted for drug development. Furthermore, GHRP-2 can stimulate the thymus to produce more T-cells, which are critical for adaptive immunity and fighting off infections.
With age, the thymus function declines, which can lead to various age-related dysfunctions. GHRP-2 has been shown to rejuvenate the thymus, leading to improved immunity.
The primary concern for peptide researchers today is product purity. Nord-sci guarantees our product purity by performing independent testing of our products and providing those certifications for our customers in our product descriptions.
THIS PRODUCT IS NOT INTENDED TO TREAT, CURE OR DIAGNOSE ANY CONDITION OR DISEASE AND IS NOT FOR HUMAN CONSUMPTION.
ALL PRODUCTS OFFERED ARE INTENDED FOR LABORATORY RESEARCH USE ONLY.
Mix each vial with: Bacteriostatic water. 1-2ml depending on desired dissolution.
Administration: 0.3 mg/ 5-7 times per day
GHRP-2 Peptide (5 mg) – Product Description
GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide designed for advanced investigation of growth hormone axis physiology, ghrelin receptor signaling, and downstream metabolic pathways in preclinical and in vitro models. This research-grade peptide is manufactured via chemical synthesis and supplied as a lyophilized powder for precise laboratory protocol design.
As a selective agonist of the growth hormone secretagogue receptor (GHS-R1a), GHRP-2 has been evaluated in animal and cell systems for its ability to modulate pulsatile growth hormone (GH) release, influence IGF-1–linked cascades, and interact with appetite and energy balance signaling. Nordsci GHRP-2 is produced to stringent analytical specifications and is intended exclusively for controlled scientific research.
GHRP-2 Research Peptide Specifications:
| Unit Size | 5 mg/vial |
| Unit Quantity | 1 vial |
| Purity (HPLC) | ≥ 99% |
| Peptide Type | Growth Hormone Releasing Peptide-2 (GHRP-2) |
| Sequence | D-Ala–D-2-Nal–Ala–Trp–D-Phe–Lys–NH2 |
| Molecular Formula | C45H55N9O6 |
| Molecular Weight | ~817.0 g/mol |
| Appearance | Lyophilized white to off-white powder |
| Source | Chemical synthesis |
| Storage Conditions | Store lyophilized GHRP-2 at -20 °C in a dry, dark environment. After reconstitution, keep aliquots refrigerated and use within protocol-defined stability windows. |
| Research Use Only | For laboratory research use only. Not for human consumption, clinical treatment, diagnostic use, or veterinary applications. |
What Is GHRP-2? Research Background and Mechanism
GHRP-2 is a second-generation growth hormone secretagogue that binds to the ghrelin receptor (GHS-R1a) expressed in the pituitary and hypothalamus. In preclinical models, GHRP-2 has been shown to stimulate pulsatile GH release, interact synergistically with GHRH (growth hormone–releasing hormone), and modulate downstream IGF-1–related signaling cascades under controlled conditions.
By acting as a ghrelin mimetic, GHRP-2 enables investigators to probe:
- Receptor-level control of GH secretion from pituitary somatotrophs
- Feedback relationships between GH, IGF-1, and metabolic endpoints
- Cross-talk between energy intake signals and endocrine output
- Stress, sleep, and circadian influences on GH pulse frequency and amplitude
These properties make GHRP-2 a useful tool compound for dissecting the GH axis, evaluating growth hormone secretagogue receptor pharmacology, and comparing different GHS-class peptides under standardized assay conditions.
Important Research Notice: All mechanistic discussion is derived from animal and in vitro data. GHRP-2 from Nordsci is not approved as a drug or therapy and must never be used for self-administration or any non-research purpose.
GHRP-2 in Growth Hormone Axis and Endocrine Research
1. GH Pulse Dynamics and GHS-R1a Pharmacology
Preclinical studies have used GHRP-2 to characterize how GHS-R1a agonism alters GH pulse amplitude, frequency, and total GH output. Typical research endpoints include:
- Serial GH measurements following controlled GHRP-2 exposure
- Comparative analyses versus other GHS peptides (e.g., GHRP-6, Hexarelin, Ipamorelin)
- Assessment of synergy with GHRH analogs versus monotherapy conditions
- Receptor desensitization and recovery kinetics with repeated stimulation
2. Metabolic and Body Composition Models
Because growth hormone influences lipolysis, carbohydrate handling, and lean mass accrual in animal models, GHRP-2 is often integrated into broader metabolic research frameworks. Investigators may explore:
- Changes in body composition, adipose distribution, and lean tissue markers in rodents
- Interactions with high-fat or calorie-restricted diet protocols
- Glucose tolerance, insulin sensitivity indices, and fasting metabolic panels
- Comparative analysis against other peptides studied for weight-related endpoints, including AOD-9604 and Hexarelin
3. Recovery, Stress, and Sleep-Linked Endpoints
GH-related pathways intersect with sleep architecture, recovery capacity, and tissue remodeling in preclinical settings. GHRP-2 can be utilized in research programs to:
- Model GH-linked contributions to recovery following controlled physical stressors
- Study the interplay between GH pulses and sleep-wake cycles in animal models
- Examine GH axis responses under chronic stress or glucocorticoid exposure
- Compare growth hormone secretagogues as tools in multi-peptide research stacks
GHRP-2 Reconstitution and Laboratory Handling
Reconstitution Guidelines (Research Use Only):
Reconstitute each vial with a suitable sterile laboratory diluent (e.g., bacteriostatic water or other protocol-approved vehicle) to achieve the desired working concentration for in vitro or animal model use. Concentrations, dosing intervals, and exposure windows should be determined by institutional protocols, existing literature, and study objectives.
Note: Reconstitution instructions are provided strictly as high-level research guidance. All experimental work must be approved by the relevant institutional animal care and ethics committees and conducted by qualified personnel in appropriately equipped laboratories.
GHRP-2 Certificate of Analysis (COA) and Quality Controls
Nordsci GHRP-2 undergoes independent third-party analytical testing to verify identity and purity before release. Each batch is supported by:
- High-performance liquid chromatography (HPLC) purity analysis
- Mass spectrometry confirmation of molecular weight
- Documentation of lot number, production date, and storage recommendations
COA documentation is available to qualified research institutions for internal record-keeping, protocol development, and regulatory audits.
Where to Buy GHRP-2 for Research Purposes
GHRP-2 should be sourced only from specialized peptide suppliers that clearly label products for research use, provide detailed analytical documentation, and maintain robust quality standards. Nordsci Peptides focuses on supplying GHRP-2 and complementary GH-axis research compounds to professional laboratories and investigators.
Before integrating GHRP-2 into any experimental protocol, research teams should validate:
- Alignment of product specifications with study requirements
- Availability of complete COA and analytical data
- Segregation between research-only materials and any clinical or GMP inventory within the facility
THIS PRODUCT IS INTENDED FOR LABORATORY RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION. NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE OR CONDITION.
Scientific References
- Smith RG, et al. Growth hormone secretagogues and the ghrelin receptor: endocrine and metabolic effects. J Clin Invest.
- Popovic V, et al. GH-releasing peptide studies in humans and animals: insights into GH regulation. Horm Res.
- Deghenghi R, et al. Development of GHRP-2 as a growth hormone secretagogue: preclinical findings. Peptides.
- Gauna C, et al. Ghrelin and synthetic GHS effects on GH/IGF-1 axis and metabolism. Eur J Endocrinol.