Hexarelin Peptide – Product Description
Hexarelin is a synthetic growth hormone secretagogue (GHS) peptide supplied for controlled laboratory research on growth hormone (GH) release, pituitary signaling, and cardiometabolic pathways. This research-grade hexapeptide is manufactured to tight specifications and validated by third-party analytical testing to support reproducible preclinical work.
Hexarelin Research Peptide Specifications:
| Unit Size |
5 mg/vial |
| Unit Quantity |
1 vial |
| Purity (HPLC) |
> 99% |
| Sequence |
His–D-2-methyl-Trp–Ala–Trp–D-Phe–Lys–NH2 |
| Molecular Formula |
C47H58N12O6 |
| Molecular Weight |
887.0 g/mol (approx.) |
| CAS Number |
140703-51-1 |
| Appearance |
Lyophilized white to off-white powder |
| Source |
Chemical Synthesis |
| Storage Conditions |
Store lyophilized Hexarelin at -20°C in a dry, dark environment. After reconstitution, store at 4°C and use within the recommended research holding period in accordance with institutional guidelines. |
| Research Use Only |
This research peptide is intended for laboratory research use only. Not for human consumption, clinical use, or therapeutic applications. Please review our terms of service prior to ordering. |
What is Hexarelin? Research Background and Mechanism
Hexarelin (also known as examorelin) is a synthetic hexapeptide growth hormone secretagogue that selectively binds to the growth hormone secretagogue receptor (GHS-R1a), part of the ghrelin receptor family. By engaging this receptor on pituitary somatotrophs and hypothalamic neurons, Hexarelin has been shown in preclinical and early clinical research to stimulate pulsatile GH release.[1,2]
Unlike endogenous ghrelin, Hexarelin is structurally optimized for increased stability and potency at the GHS-R1a receptor. Laboratory investigations have evaluated Hexarelin as a model compound for dissecting GH axis regulation, as well as for exploring downstream effects on metabolism, body composition, and cardiovascular signaling.[1–3]
Key research domains include:
- Growth hormone pulsatility and IGF-1 axis modulation
- Cardioprotective signaling and myocardial remodeling
- Bone and muscle tissue responses to GH secretagogue stimulation
- Metabolic and adiposity-related endpoints in preclinical models
Hexarelin Research Focus Areas
1. Growth Hormone Secretion and Endocrine Axis Modulation
Hexarelin has been investigated extensively for its capacity to stimulate GH release via GHS-R1a activation. In preclinical studies and early human trials, Hexarelin has shown robust GH secretagogue effects, including enhanced amplitude and frequency of GH pulses.[1,2] These responses have been evaluated in the context of age-related GH decline, hypothalamic–pituitary axis dysregulation, and pharmacologic GH stimulation testing.
Researchers use Hexarelin to:
- Map the dynamics of GH release and feedback via somatostatin and GHRH
- Compare different GHS analogs and their receptor-binding profiles
- Characterize relationships between GH pulses, IGF-1 levels, and downstream tissue effects
2. Cardiovascular and Myocardial Protection Models
One of the most active areas of Hexarelin research involves its cardiometabolic and myocardial effects. In animal models of myocardial infarction, heart failure, and cardiotoxicity, Hexarelin has been studied for potential cardioprotective properties, including effects on left ventricular function, fibrosis, and apoptotic signaling.[3–5]
These investigations often focus on:
- GHS-R1a expression in cardiac tissue
- Modulation of pro-survival pathways and anti-apoptotic signaling
- Remodeling of ventricular geometry and contractility post-injury
3. Bone, Muscle, and Body-Composition Research
Because growth hormone plays a central role in musculoskeletal integrity, Hexarelin has been evaluated in models of bone density, muscle mass, and frailty. Preclinical work has examined how chronic or intermittent GHS stimulation may impact bone mineral content, trabecular architecture, and lean mass, particularly in the context of aging or glucocorticoid exposure.[2,4]
Laboratories also deploy Hexarelin alongside other GH secretagogues and peptides to build comparative datasets on:
- GH-dependent vs. GH-independent musculoskeletal effects
- Interactions with IGF-1 and other anabolic pathways
- Potential synergy with exercise or mechanical loading in experimental systems
4. Metabolic and Weight-Related Endpoints
Although Hexarelin is not primarily a “weight-loss peptide,” GH axis modulation has implications for adiposity, lipid handling, and insulin sensitivity. Preclinical work has therefore begun to incorporate Hexarelin into broader metabolic frameworks, including diet-induced obesity models and insulin-resistance paradigms.[3–5]
These studies leverage Hexarelin to better understand how GH pulsatility, energy expenditure, and substrate utilization intersect, particularly when compared or combined with other metabolic research peptides.
Important Research Notice: Nordsci peptides undergo independent third-party laboratory testing to verify purity and identity. Certificate of Analysis (COA) documentation is available for each research lot to support rigorous scientific methods and quality assurance.
THIS PRODUCT IS INTENDED FOR LABORATORY RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION. NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE OR CONDITION.
Hexarelin Certificate of Analysis (COA) – Lab Testing
Nordsci provides batch-specific analytical documentation for Hexarelin, including HPLC chromatograms and mass spectrometry identity confirmation.
Download Hexarelin COA Lab Test Results
Where to Buy Hexarelin for Research Purposes
Research-grade Hexarelin should be sourced from suppliers capable of delivering high-purity peptide, validated identity, and transparent quality documentation. Nordsci specializes in research-only peptides and stacks that support rigorous preclinical design, with a focus on consistency across lots and clearly defined specifications.
How to Source Hexarelin for Laboratory Research
When evaluating suppliers, researchers should confirm that each lot of Hexarelin is accompanied by:
- A Certificate of Analysis (COA) with HPLC and mass spectrometry data
- Documented peptide sequence, molecular characteristics, and storage guidance
- Clear “research use only” designation aligned with non-clinical applications
Hexarelin Research Peptide Pricing Considerations
Pricing for Hexarelin varies according to purity grade, quantity, and formulation strategy (e.g., stand-alone peptide vs. integration into GH-optimization stacks). Procurement teams should also budget for appropriate storage, handling, and any additional analytical confirmation required by institutional policy.
Research Institution Procurement and Compliance
Principal investigators and purchasing teams should ensure that Hexarelin acquisition aligns with internal purchasing policies, chemical inventory management systems, and safety documentation requirements. Proper labeling, secure storage, and controlled access are essential to support compliant, long-term research programs involving GH secretagogues.
IMPORTANT: Hexarelin is sold exclusively for in vitro research and laboratory applications. It is not approved for human use, clinical protocols, or any therapeutic application. Researchers are responsible for adhering to all applicable regulations governing peptide research in their jurisdiction.
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