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Hexarelin (5mg)

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Hexarelin Acetate is a synthetic hexapeptide that stimulates the release of growth hormone (GH) without interfering with the body's natural production of GH. Its structure is similar to that of GHRP-6 (LINK TO GHRP-6) but without causing an increase in appetite due to its inability to significantly increase Ghrelin levels, which is responsible for appetite stimulation and gastric emptying.

Hexarelin is a synthetic growth hormone secretagogue made up of six amino acids, which has been shown in studies to reduce visceral fat over time. Individuals using IGF-1 typically experience increased strength and muscle mass as well as significant fat loss.

Studies conducted on rats have shown that GHRP-6 has the potential to correct dyslipidemia while simultaneously reducing blood sugar and insulin resistance. This peptide could serve as an alternative to existing lipid medications for treating severe dyslipidemia. Furthermore, research indicates that Hexarelin not only protects the heart muscle but also regulates calcium flow and mitochondrial dysfunction.

 

 

The primary concern for peptide researchers today is product purity. Nord-sci guarantees our product purity by performing independent testing of our products and providing those certifications for our customers in our product descriptions.

THIS PRODUCT IS NOT INTENDED TO TREAT, CURE OR DIAGNOSE ANY CONDITION OR DISEASE AND IS NOT FOR HUMAN CONSUMPTION. ALL PRODUCTS OFFERED ARE INTENDED FOR LABORATORY RESEARCH USE ONLY.

All products are produced using lyophilization (freeze-drying), a preservation method that allows peptides to remain fully stable during shipping for approximately 3-4 months. Once a peptide has been reconstituted with bacteriostatic water, it must be refrigerated to maintain integrity. After reconstitution, peptides typically remain stable for up to 30 days when stored properly.

Lyophilization, also referred to as cryodesiccation, is a specialized dehydration process in which peptides are first frozen and then exposed to a low-pressure environment. This causes the water within the vial to transition directly from a solid to a vapor (sublimation), leaving behind a dry, crystalline white material known as a lyophilized peptide. In this powdered form, peptides may be safely stored at room temperature until they are ready to be reconstituted with bacteriostatic water.

After delivery, peptides should be protected from heat and light. If use is expected within the near future (whether days, weeks, or a few months) refrigerated storage below 4°C (39°F) is generally sufficient. Lyophilized peptides are commonly stable at room temperature for several weeks or longer, making short-term ambient storage acceptable when use is anticipated within that timeframe.

For extended storage, ranging from several months to multiple years, freezing is strongly recommended. Storage at -80°C (-112°F) offers optimal long-term stability and helps preserve peptide structure and quality over time.

For more detailed guidance on peptide handling and storage best practices, please refer to the resource below:

Peptide Storage and Stability: Best Practices for Every Lab

Hexarelin (5mg)

Regular Price
$46.00
Sale Price
$46.00
Regular Price
Sold Out
Unit Price
per

Hexarelin Peptide – Product Description

Hexarelin is a synthetic growth hormone secretagogue (GHS) peptide supplied for controlled laboratory research on growth hormone (GH) release, pituitary signaling, and cardiometabolic pathways. This research-grade hexapeptide is manufactured to tight specifications and validated by third-party analytical testing to support reproducible preclinical work.

Hexarelin Research Peptide Specifications:

Unit Size 5 mg/vial
Unit Quantity 1 vial
Purity (HPLC) > 99%
Sequence His–D-2-methyl-Trp–Ala–Trp–D-Phe–Lys–NH2
Molecular Formula C47H58N12O6
Molecular Weight 887.0 g/mol (approx.)
CAS Number 140703-51-1
Appearance Lyophilized white to off-white powder
Source Chemical Synthesis
Storage Conditions Store lyophilized Hexarelin at -20°C in a dry, dark environment. After reconstitution, store at 4°C and use within the recommended research holding period in accordance with institutional guidelines.
Research Use Only This research peptide is intended for laboratory research use only. Not for human consumption, clinical use, or therapeutic applications. Please review our terms of service prior to ordering.

What is Hexarelin? Research Background and Mechanism

Hexarelin (also known as examorelin) is a synthetic hexapeptide growth hormone secretagogue that selectively binds to the growth hormone secretagogue receptor (GHS-R1a), part of the ghrelin receptor family. By engaging this receptor on pituitary somatotrophs and hypothalamic neurons, Hexarelin has been shown in preclinical and early clinical research to stimulate pulsatile GH release.[1,2]

Unlike endogenous ghrelin, Hexarelin is structurally optimized for increased stability and potency at the GHS-R1a receptor. Laboratory investigations have evaluated Hexarelin as a model compound for dissecting GH axis regulation, as well as for exploring downstream effects on metabolism, body composition, and cardiovascular signaling.[1–3]

Key research domains include:

  • Growth hormone pulsatility and IGF-1 axis modulation
  • Cardioprotective signaling and myocardial remodeling
  • Bone and muscle tissue responses to GH secretagogue stimulation
  • Metabolic and adiposity-related endpoints in preclinical models

Hexarelin Research Focus Areas

1. Growth Hormone Secretion and Endocrine Axis Modulation

Hexarelin has been investigated extensively for its capacity to stimulate GH release via GHS-R1a activation. In preclinical studies and early human trials, Hexarelin has shown robust GH secretagogue effects, including enhanced amplitude and frequency of GH pulses.[1,2] These responses have been evaluated in the context of age-related GH decline, hypothalamic–pituitary axis dysregulation, and pharmacologic GH stimulation testing.

Researchers use Hexarelin to:

  • Map the dynamics of GH release and feedback via somatostatin and GHRH
  • Compare different GHS analogs and their receptor-binding profiles
  • Characterize relationships between GH pulses, IGF-1 levels, and downstream tissue effects

2. Cardiovascular and Myocardial Protection Models

One of the most active areas of Hexarelin research involves its cardiometabolic and myocardial effects. In animal models of myocardial infarction, heart failure, and cardiotoxicity, Hexarelin has been studied for potential cardioprotective properties, including effects on left ventricular function, fibrosis, and apoptotic signaling.[3–5]

These investigations often focus on:

  • GHS-R1a expression in cardiac tissue
  • Modulation of pro-survival pathways and anti-apoptotic signaling
  • Remodeling of ventricular geometry and contractility post-injury

3. Bone, Muscle, and Body-Composition Research

Because growth hormone plays a central role in musculoskeletal integrity, Hexarelin has been evaluated in models of bone density, muscle mass, and frailty. Preclinical work has examined how chronic or intermittent GHS stimulation may impact bone mineral content, trabecular architecture, and lean mass, particularly in the context of aging or glucocorticoid exposure.[2,4]

Laboratories also deploy Hexarelin alongside other GH secretagogues and peptides to build comparative datasets on:

  • GH-dependent vs. GH-independent musculoskeletal effects
  • Interactions with IGF-1 and other anabolic pathways
  • Potential synergy with exercise or mechanical loading in experimental systems

4. Metabolic and Weight-Related Endpoints

Although Hexarelin is not primarily a “weight-loss peptide,” GH axis modulation has implications for adiposity, lipid handling, and insulin sensitivity. Preclinical work has therefore begun to incorporate Hexarelin into broader metabolic frameworks, including diet-induced obesity models and insulin-resistance paradigms.[3–5]

These studies leverage Hexarelin to better understand how GH pulsatility, energy expenditure, and substrate utilization intersect, particularly when compared or combined with other metabolic research peptides.

Important Research Notice: Nordsci peptides undergo independent third-party laboratory testing to verify purity and identity. Certificate of Analysis (COA) documentation is available for each research lot to support rigorous scientific methods and quality assurance.

THIS PRODUCT IS INTENDED FOR LABORATORY RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION. NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE OR CONDITION.

Hexarelin Certificate of Analysis (COA) – Lab Testing

Nordsci provides batch-specific analytical documentation for Hexarelin, including HPLC chromatograms and mass spectrometry identity confirmation.

Download Hexarelin COA Lab Test Results

Where to Buy Hexarelin for Research Purposes

Research-grade Hexarelin should be sourced from suppliers capable of delivering high-purity peptide, validated identity, and transparent quality documentation. Nordsci specializes in research-only peptides and stacks that support rigorous preclinical design, with a focus on consistency across lots and clearly defined specifications.

How to Source Hexarelin for Laboratory Research

When evaluating suppliers, researchers should confirm that each lot of Hexarelin is accompanied by:

  • A Certificate of Analysis (COA) with HPLC and mass spectrometry data
  • Documented peptide sequence, molecular characteristics, and storage guidance
  • Clear “research use only” designation aligned with non-clinical applications

Hexarelin Research Peptide Pricing Considerations

Pricing for Hexarelin varies according to purity grade, quantity, and formulation strategy (e.g., stand-alone peptide vs. integration into GH-optimization stacks). Procurement teams should also budget for appropriate storage, handling, and any additional analytical confirmation required by institutional policy.

Research Institution Procurement and Compliance

Principal investigators and purchasing teams should ensure that Hexarelin acquisition aligns with internal purchasing policies, chemical inventory management systems, and safety documentation requirements. Proper labeling, secure storage, and controlled access are essential to support compliant, long-term research programs involving GH secretagogues.

IMPORTANT: Hexarelin is sold exclusively for in vitro research and laboratory applications. It is not approved for human use, clinical protocols, or any therapeutic application. Researchers are responsible for adhering to all applicable regulations governing peptide research in their jurisdiction.

Scientific References

  1. Bowers CY, et al. Hexarelin, a peptidyl growth hormone secretagogue, and the regulation of GH secretion in humans. J Clin Endocrinol Metab. 1997.
  2. Ghigo E, et al. Growth hormone-releasing peptides. Eur J Endocrinol. 2000.
  3. Poehlman ET, et al. Effects of GH secretagogues on body composition and endocrine function: insights from preclinical and clinical models. Horm Res. 2005.
  4. Bisi G, et al. Cardiovascular effects of Hexarelin in experimental heart failure. Endocrine. 2003.
  5. Bunek R, et al. Growth hormone secretagogues and the cardiovascular system. Ann Endocrinol (Paris). 2003.

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body.  These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease.  Bodily introduction of any kind into humans or animals is strictly forbidden by law.