MOTS-C (10mg)

MOTS-C Peptide – Product Description

MOTS-C is a high-purity research peptide designed to support advanced investigation of cellular energy regulation, mitochondrial signaling, and metabolic stress responses in controlled laboratory models. As a mitochondrial-derived peptide, MOTS-C is of growing interest in preclinical research programs focused on exercise physiology, metabolic adaptation, and healthy aging pathways.

This MOTS-C research peptide is synthesized to strict quality standards and undergoes independent third-party analytical testing to verify identity and purity, providing a reliable tool for investigators designing reproducible metabolic and longevity-oriented research protocols.

MOTS-C Research Peptide Specifications:

What Is MOTS-C? Research Background and Mechanistic Focus

MOTS-C is a mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S rRNA region and translated in the cytoplasm. In preclinical models, it has been studied as a regulator of cellular energy metabolism, nutrient-sensing pathways, and stress adaptation signaling. Laboratory research suggests that MOTS-C can engage key molecular nodes associated with AMPK activation, metabolic flexibility, and resilience to metabolic stress at the cellular level.

Researchers utilize MOTS-C in cell culture and animal models to:

• Interrogate the crosstalk between mitochondrial signals and nuclear gene expression
• Characterize metabolic responses to nutrient overload, caloric restriction, and exercise-mimetic conditions
• Explore how mitochondrial peptides influence insulin sensitivity markers and glucose handling in preclinical systems
• Study adaptive stress responses under oxidative, metabolic, or inflammatory challenge conditions

Because of its mitochondrial origin and signaling profile, MOTS-C occupies a unique position in research investigating the intersection of energy metabolism, longevity biology, and systemic stress responses.

Key MOTS-C Research Areas

Metabolic Homeostasis and Energy Regulation

Preclinical models frequently deploy MOTS-C to evaluate how mitochondrial-derived signals reshape cellular energy balance. Investigators focus on endpoints such as glucose uptake, mitochondrial function markers, fatty acid utilization, and downstream transcriptional networks involved in metabolic adaptation.

Exercise Physiology and Stress Adaptation Models

In exercise-mimetic and performance-oriented research, MOTS-C is often introduced into study designs that examine skeletal muscle bioenergetics, fatigue resistance, and recovery dynamics. This allows researchers to evaluate how mitochondrial peptides may modulate training adaptations, stress tolerance, and recovery trajectories in laboratory animals.

Aging, Longevity, and Cellular Resilience

Because mitochondrial function and energy regulation are central to aging biology, MOTS-C has attracted interest in experimental frameworks focused on healthy aging, resilience under stress, and mitigation of age-associated decline in metabolic flexibility. These models remain strictly preclinical and are used to generate mechanistic insights rather than therapeutic recommendations.

MOTS-C Reconstitution and Laboratory Handling

Reconstitution Guidelines for Laboratory Use (General Framework):

In research settings, lyophilized MOTS-C is typically reconstituted with sterile diluents such as bacteriostatic water for injection or another institution-approved vehicle. Investigators determine final concentrations based on experimental design, assay sensitivity, and model type.

Common laboratory best practices include:

• Allowing the vial to reach room temperature before opening to reduce condensation
• Adding the desired volume of sterile diluent slowly along the vial wall to minimize foaming
• Gently swirling (not vigorously shaking) until material is fully dissolved
• Aliquoting reconstituted peptide into smaller volumes to limit freeze–thaw cycles
• Documenting concentration, diluent type, reconstitution date, and lot number in laboratory records

Note: All specific concentration ranges, schedules, and endpoints must be defined by the research institution. This information is provided solely as a general laboratory reference framework, not as protocol guidance for clinical or human use.

Quality Control, COA, and Research Compliance

Each MOTS-C research lot is supported by third-party analytical testing to confirm peptide identity and purity. Certificate of Analysis (COA) documentation is available for institutions that require detailed characterization, including HPLC and mass spectrometry data, to support internal quality, regulatory, and audit requirements.

Research teams typically integrate MOTS-C into their workflows by:

• Verifying that institutional IACUC and biosafety protocols permit use of mitochondrial-derived peptides in the intended models
• Maintaining traceability of lot numbers, storage conditions, and in-use durations
• Incorporating peptide-free vehicle controls to distinguish MOTS-C–specific effects from background signal
• Capturing all MOTS-C–related methods and concentrations transparently in internal reports and publications

Where to Source MOTS-C for Research

When acquiring MOTS-C, research organizations prioritize suppliers that specialize in research-only peptides and maintain robust analytical documentation. Nordsci Peptides focuses on research-grade peptide sourcing, providing COA-backed inventory, batch-level traceability, and clear research-only positioning for regulatory alignment.

By centralizing peptide sourcing, documentation, and storage under consistent internal SOPs, institutions can integrate MOTS-C into broader metabolic, mitochondrial, and aging research pipelines while preserving data integrity and reproducibility across studies.

THIS PRODUCT IS INTENDED FOR LABORATORY RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION. NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE OR CONDITION.

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body.  These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease.  Bodily introduction of any kind into humans or animals is strictly forbidden by law.