FOXO4-DRI is a synthetic peptide designed to disrupt the interaction between the FOXO4 transcription factor and p53, a pathway of interest in cellular senescence research. FOXO4 plays a key role in regulating cell cycle control, stress resistance, and apoptosis, while p53 is a central regulator of DNA damage response and cellular aging. By selectively interfering with the FOXO4-p53 interaction, FOXO4-DRI has become a compound of interest in research models focused on senescent cell biology and age-associated cellular processes. FOXO4-DRI is supplied in lyophilized form strictly for controlled laboratory research applications.
Prior to the development of FOXO4-DRI, research into cellular senescence largely relied on indirect markers of aging, generalized apoptosis pathways, or broad-spectrum senolytic compounds. Preclinical research introduced FOXO4-DRI as a targeted approach for studying senescent cell survival mechanisms by modulating transcription factor interactions rather than global cytotoxic activity. These findings positioned FOXO4-DRI as a specialized research tool for investigating senescence-associated signaling, stress response pathways, and cell fate determination in aging models.
Currently, FOXO4-DRI is being investigated for its role in studies involving cellular senescence, transcription factor regulation, DNA damage response signaling, and aging-related cellular models. Additional research is exploring its utility in examining selective senescent cell vulnerability, apoptosis signaling mechanisms, and the molecular regulation of cell survival under chronic stress conditions. As research continues, FOXO4-DRI remains a compelling compound for ongoing laboratory investigation into senescence biology and transcriptional control mechanisms.
The primary concern for peptide researchers today is product purity. Nord-sci guarantees our product purity by performing independent testing of our products and providing those certifications for our customers in our product descriptions.
THIS PRODUCT IS NOT INTENDED TO TREAT, CURE OR DIAGNOSE ANY CONDITION OR DISEASE AND IS NOT FOR HUMAN CONSUMPTION. ALL PRODUCTS OFFERED ARE INTENDED FOR LABORATORY RESEARCH USE ONLY."
All products are produced using lyophilization (freeze-drying), a preservation method that allows peptides to remain fully stable during shipping for approximately 3-4 months. Once a peptide has been reconstituted with bacteriostatic water, it must be refrigerated to maintain integrity. After reconstitution, peptides typically remain stable for up to 30 days when stored properly.
Lyophilization, also referred to as cryodesiccation, is a specialized dehydration process in which peptides are first frozen and then exposed to a low-pressure environment. This causes the water within the vial to transition directly from a solid to a vapor (sublimation), leaving behind a dry, crystalline white material known as a lyophilized peptide. In this powdered form, peptides may be safely stored at room temperature until they are ready to be reconstituted with bacteriostatic water.
After delivery, peptides should be protected from heat and light. If use is expected within the near future (whether days, weeks, or a few months) refrigerated storage below 4°C (39°F) is generally sufficient. Lyophilized peptides are commonly stable at room temperature for several weeks or longer, making short-term ambient storage acceptable when use is anticipated within that timeframe.
For extended storage, ranging from several months to multiple years, freezing is strongly recommended. Storage at -80°C (-112°F) offers optimal long-term stability and helps preserve peptide structure and quality over time.
For more detailed guidance on peptide handling and storage best practices, please refer to the resource below:
FOXO4-DRI (10mg) is a synthetic peptide studied in laboratory environments for its interaction with cellular senescence signaling pathways. In experimental models, FOXO4-DRI has been investigated for its relationship with transcription factor signaling systems associated with cellular aging, stress-response mechanisms, and senescent cell regulation. This compound is supplied strictly for controlled laboratory research applications focused on cellular longevity pathways and molecular signaling systems involved in senescence biology.
Cellular senescence is a biological state in which cells cease to divide but remain metabolically active. Senescent cells accumulate over time in tissues and may influence surrounding cellular environments through signaling molecules and inflammatory mediators. Researchers studying aging biology frequently investigate compounds capable of interacting with molecular pathways associated with senescent cell signaling.
FOXO4-DRI (10mg) – Research Specifications:
| Compound | FOXO4-DRI |
| Quantity | 10mg per vial |
| Compound Type | Synthetic peptide studied for senescence-related signaling pathways |
| Purity / Identity | Research-grade; refer to Certificate of Analysis (COA) for lot-specific analytical verification |
| Appearance | Lyophilized peptide powder |
| Storage Conditions | Store sealed in a cool, dry environment protected from heat, light, and moisture |
| Research Use Only | Supplied exclusively for laboratory research use. Not for human consumption. |
FOXO4-DRI is a peptide engineered to interact with molecular pathways involving the FOXO4 transcription factor and p53 signaling proteins. These pathways play an important role in regulating cellular stress responses, apoptosis signaling, and the maintenance of genomic stability. Laboratory investigations into FOXO4-related signaling systems aim to better understand how aging-related cellular processes are regulated at the molecular level.
The FOXO family of transcription factors is involved in coordinating cellular responses to oxidative stress, DNA damage, and metabolic signaling. In senescent cells, interactions between FOXO proteins and other regulatory molecules can influence survival signals and stress-response pathways. Because of this, compounds designed to interact with FOXO signaling have become a focus of research into cellular aging mechanisms.
Research programs examining senescence biology often intersect with broader studies of mitochondrial function, inflammatory signaling, and cellular repair pathways. FOXO4-DRI has therefore become a topic of interest in experimental models investigating molecular pathways involved in aging-related cellular signaling systems.
Important Research Notice: Nordsci research materials are supported by lot-specific analytical documentation. Certificates of Analysis are available for laboratories requiring verification of compound identity and analytical quality standards.
THIS PRODUCT IS INTENDED FOR LABORATORY RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION. NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE OR CONDITION.
Cellular senescence plays an important role in aging biology and tissue maintenance. Laboratory studies may investigate how compounds interacting with FOXO-related signaling pathways influence senescent cell behavior in controlled experimental models.
Transcription factors regulate gene expression and cellular response to environmental stress. Experimental research programs may examine how peptides designed to interact with transcription factor pathways influence gene regulatory systems.
Cells respond to oxidative stress through coordinated signaling pathways that regulate DNA repair, metabolic adaptation, and survival mechanisms. Researchers may investigate how compounds interacting with FOXO signaling pathways influence oxidative stress response systems.
Longevity research explores the molecular mechanisms that influence cellular lifespan and tissue stability. Laboratory models may evaluate how signaling compounds interact with regulatory pathways associated with aging-related cellular processes.
FOXO4-DRI (10mg) should be handled according to established laboratory procedures used for peptide research materials. Proper storage conditions, environmental controls, and documentation of experimental variables help support reliable and reproducible outcomes in cellular signaling research programs.
Protocol Design Considerations: Senescence-related research may be influenced by variables including oxidative stress exposure, DNA damage signaling, metabolic activity, and cellular environmental conditions. Researchers should maintain strict experimental controls when designing studies involving transcription factor signaling compounds.
Note: The information above is provided strictly for laboratory research reference purposes. All experiments should be conducted by qualified personnel within appropriate laboratory environments.
Each lot of FOXO4-DRI supplied by Nordsci Peptides includes a Certificate of Analysis confirming compound identity and analytical purity verification. These reports support laboratory documentation standards and traceability requirements within controlled research programs.
Laboratories sourcing peptide compounds typically prioritize analytical transparency, batch traceability, and consistent manufacturing standards. Nordsci Peptides supplies research-grade peptide compounds supported by analytical verification designed to support reliable laboratory research workflows.
IMPORTANT: FOXO4-DRI (10mg) is supplied exclusively for laboratory research use. It is not approved for human consumption or therapeutic use. Researchers are responsible for ensuring compliance with all applicable institutional and regulatory guidelines governing research materials.
