Tesamorelin is a synthetic analogue of the growth hormone-releasing hormone (GHRH) that includes an extra trans-3-hexanoic acid group. Developed by Theratechnologies in Canada, tesamorelin was approved by the FDA in 2010 as a treatment for HIV-associated lipodystrophy. This condition results in abnormal accumulation of fat in the abdomen and other areas of the body, often as a result of antiretroviral therapy.
Before the approval of tesamorelin, patients had few effective treatment options beyond diet and exercise, and surgical intervention was often unsuccessful. Tesamorelin has been found to reduce adiposity by almost 20%, making it significantly more effective than other available treatments.
Currently, tesamorelin is being investigated for its potential to reduce cardiovascular disease in individuals with HIV, promote peripheral nerve regeneration, and slow the progression of mild cognitive impairment (MCI), a precursor to dementia. Ongoing clinical trials are exploring these potential therapeutic applications. As tesamorelin is already approved by the FDA for use in humans, it is a promising subject for continued research.
The primary concern for peptide researchers today is product purity. Nord-sci guarantees our product purity by performing independent testing of our products and providing those certifications for our customers in our product descriptions.
THIS PRODUCT IS NOT INTENDED TO TREAT, CURE OR DIAGNOSE ANY CONDITION OR DISEASE AND IS NOT FOR HUMAN CONSUMPTION. ALL PRODUCTS OFFERED ARE INTENDED FOR LABORATORY RESEARCH USE ONLY.
All products are produced using lyophilization (freeze-drying), a preservation method that allows peptides to remain fully stable during shipping for approximately 3-4 months. Once a peptide has been reconstituted with bacteriostatic water, it must be refrigerated to maintain integrity. After reconstitution, peptides typically remain stable for up to 30 days when stored properly.
Lyophilization, also referred to as cryodesiccation, is a specialized dehydration process in which peptides are first frozen and then exposed to a low-pressure environment. This causes the water within the vial to transition directly from a solid to a vapor (sublimation), leaving behind a dry, crystalline white material known as a lyophilized peptide. In this powdered form, peptides may be safely stored at room temperature until they are ready to be reconstituted with bacteriostatic water.
After delivery, peptides should be protected from heat and light. If use is expected within the near future (whether days, weeks, or a few months) refrigerated storage below 4°C (39°F) is generally sufficient. Lyophilized peptides are commonly stable at room temperature for several weeks or longer, making short-term ambient storage acceptable when use is anticipated within that timeframe.
For extended storage, ranging from several months to multiple years, freezing is strongly recommended. Storage at -80°C (-112°F) offers optimal long-term stability and helps preserve peptide structure and quality over time.
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Tesamorilin is a synthetic analogue of growth hormone–releasing hormone (GHRH) formulated for controlled laboratory investigation of growth-hormone axis signaling, endocrine feedback loops, and downstream metabolic pathways. In research contexts, it is commonly used as a tool compound to evaluate pulsatile GH release patterns and related endpoints such as IGF-1 signaling, adipose tissue dynamics, and tissue-repair biomarkers. Each vial is produced to research-grade standards and supported by analytical testing designed to help laboratories maintain reproducibility across study cohorts.
Tesamorilin Research Peptide Specifications:
| Unit Size | 2 mg or 5 mg/vial |
| Unit Quantity | 1 vial |
| Purity (HPLC) | 98.4% |
| Sequence | Unk-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2.CH3CO2H |
| Molecular Formula | C221H366N72O67S |
| Molecular Weight | 5135.86 g/mol |
| CAS Number | 901758-09-6 |
| Appearance | Lyophilized White Powder |
| Source | Chemical Synthesis |
| Storage Conditions | Store lyophilized Tesamorilin in a cool, dry environment with minimal air exposure, protected from light and moisture. Reconstituted solutions should be handled under sterile conditions, stored cold, and used according to internal laboratory SOPs and institutional requirements. |
| Research Use Only | This peptide is supplied exclusively for laboratory research use. Not for human consumption, clinical use, or veterinary applications. Please review all terms and conditions prior to purchase. |
Tesamorilin is engineered to model GHRH-driven signaling in a controlled, measurable way. In endocrine research design, GHRH analogs are used to evaluate how upstream hypothalamic signals translate into pituitary growth hormone output, and how that output propagates into downstream growth-factor and metabolic cascades.
From a mechanistic standpoint, tesamorilin is most often positioned in GH-axis studies alongside complementary tools such as Sermorelin and secretagogues that operate via different receptors (e.g., GHRP-2 and GHRP-6). This enables comparative protocols that distinguish GHRH-receptor signaling from ghrelin-receptor signaling, while tracking shared endpoints like IGF-1 response profiles and tissue-level biomarker shifts.
It is also frequently discussed in the context of body-composition research frameworks where investigators evaluate visceral adipose tissue (VAT) markers, lipid handling, and metabolic readouts over time. Importantly, these are laboratory and clinical-literature reference points, not product claims for consumer use.
Important Research Notice: Nordsci peptides are supported by independent third-party analytical testing to validate identity and purity via HPLC and mass spectrometry. A Certificate of Analysis (COA) is available for each lot to help labs align with internal quality management and documentation requirements.
THIS PRODUCT IS INTENDED FOR LABORATORY RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION. NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE OR CONDITION.
In GH-axis research, the primary value of tesamorilin is its usefulness as a structured probe for endocrine signaling. Laboratories may track pituitary GH output patterns and downstream markers over defined intervals, especially when comparing response profiles against other GH-relevant compounds such as CJC 1295 (without DAC) or Ipamorelin. This supports more precise attribution of observed outcomes to receptor-level differences, not just overall GH exposure.
Peer-reviewed clinical literature has evaluated tesamorelin in contexts where visceral adiposity and lipid markers are tracked over time. For research teams building translational models, these data points are often used to inform hypothesis framing, biomarker selection, and study-horizon planning, particularly when differentiating VAT-driven outcomes from broader weight-related metrics.
Because endocrine systems are tightly networked, tesamorilin is often discussed in study designs that also examine reproductive-axis modulators and downstream hormonal cross-talk. In practice, investigators may reference adjacent research comparisons such as HCG frameworks or GH-vs-gonadotropin differentials when defining inclusion criteria, measurement cadence, and confounders for endocrine panels.
Beyond metabolic and endocrine endpoints, tesamorelin has appeared in exploratory clinical research programs that evaluate cognition-related endpoints and functional recovery models. These programs provide additional context for researchers who are mapping GH-axis influence beyond body composition alone. Any such use remains subject to strict protocol governance, ethics approvals, and study-specific constraints.
Each lot of tesamorilin is supported by a Certificate of Analysis documenting analytical verification of identity and purity. COA documentation can be used for protocol files, internal audits, and research documentation workflows that require lot-level traceability and quality reporting.
Sourcing GH-axis compounds requires a supplier that maintains consistent synthesis quality, transparent documentation, and reliable lot traceability. Nordsci Peptides focuses on research-grade peptides that support controlled experimental design and repeatable outcomes.
How to Source Tesamorilin for Laboratory Research
Before procurement, labs typically verify labeling clarity, lot identifiers, COA access, and purity validation methods. This is especially important for endocrine research compounds, where small variations in identity or handling can materially affect signal fidelity across cohorts.
IMPORTANT: Tesamorilin is supplied exclusively for controlled laboratory research. It is not intended for self-administration, clinical use, or veterinary use. Researchers are responsible for complying with all applicable regulations and institutional policies governing peptide research in their jurisdiction.
