Retatrutide is a novel investigational peptide therapy that acts as a triple agonist of the GLP-1, GIP, and glucagon receptors. This unique mechanism sets it apart from earlier GLP-1–only treatments by targeting multiple pathways involved in energy balance, glucose regulation, and fat metabolism.
Originally developed for the treatment of obesity and type 2 diabetes, Retatrutide has shown strong potential in clinical studies for promoting weight loss, improving insulin sensitivity, and enhancing cardiovascular health. By combining GLP-1 and GIP agonism (which support satiety, insulin secretion, and improved glycemic control) with glucagon receptor activation (which increases energy expenditure and fat burning), Retatrutide offers a comprehensive approach to metabolic disease management.
Clinical trials have demonstrated that Retatrutide can induce significant and sustained weight loss while also improving key markers such as blood glucose, insulin resistance, and lipid levels. Unlike traditional single-pathway therapies, its multi-receptor activity allows for greater efficacy without compromising safety.
What makes Retatrutide particularly promising is its ability to not only reduce body weight but also mobilize and oxidize stored fat, inhibit new fat accumulation, and potentially improve liver health by reducing markers of fatty liver disease. Importantly, studies so far indicate that it achieves these effects without undue risk of hypoglycemia or severe adverse metabolic disturbances.
Through ongoing clinical evaluation, Retatrutide is emerging as a powerful next-generation therapeutic candidate for obesity, type 2 diabetes, and related metabolic disorders. Designed to deliver deeper, more durable outcomes than GLP-1 therapies alone.
The primary concern for peptide researchers today is product purity. Nord-sci guarantees our product purity by performing independent testing of our products and providing those certifications for our customers in our product descriptions.
THIS PRODUCT IS NOT INTENDED TO TREAT, CURE OR DIAGNOSE ANY CONDITION OR DISEASE AND IS NOT FOR HUMAN CONSUMPTION. ALL PRODUCTS OFFERED ARE INTENDED FOR LABORATORY RESEARCH USE ONLY.
Purchasing Retatrutide safely and legally is important, and this product is for research purposes only. Nordsci will always provide essential information about legitimate purchasing channels, and pricing considerations when looking to purchase.
Legitimate sources include licensed pharmacies, compounding facilities, and authorized online platforms, with reputable telemedicine platforms offering an established and safe pathway to obtain the medication like NordsciPeptides.com.
The cost of retatrutide ranges from several hundred to over a thousand dollars per month, depending on dosage, supplier, and whether it’s purchased from compounding pharmacies or branded manufacturers. Additional costs, such as healthcare provider consultations, injection supplies, and potential supplements, should also be considered when budgeting for long-term treatment.
Insurance coverage for retatrutide is limited and varies by plan, as it is still awaiting FDA approval for weight management. Some patients, particularly those with diabetes or metabolic syndrome, may receive partial coverage with prior authorization, but they often face high copayments or deductibles, and coverage may be restricted or require regular reassessments.
All products are produced using lyophilization (freeze-drying), a preservation method that allows peptides to remain fully stable during shipping for approximately 3-4 months. Once a peptide has been reconstituted with bacteriostatic water, it must be refrigerated to maintain integrity. After reconstitution, peptides typically remain stable for up to 30 days when stored properly.
Lyophilization, also referred to as cryodesiccation, is a specialized dehydration process in which peptides are first frozen and then exposed to a low-pressure environment. This causes the water within the vial to transition directly from a solid to a vapor (sublimation), leaving behind a dry, crystalline white material known as a lyophilized peptide. In this powdered form, peptides may be safely stored at room temperature until they are ready to be reconstituted with bacteriostatic water.
After delivery, peptides should be protected from heat and light. If use is expected within the near future (whether days, weeks, or a few months) refrigerated storage below 4°C (39°F) is generally sufficient. Lyophilized peptides are commonly stable at room temperature for several weeks or longer, making short-term ambient storage acceptable when use is anticipated within that timeframe.
For extended storage, ranging from several months to multiple years, freezing is strongly recommended. Storage at -80°C (-112°F) offers optimal long-term stability and helps preserve peptide structure and quality over time.
For more detailed guidance on peptide handling and storage best practices, please refer to the resource below:
Retatrutide is a high-purity research peptide designed for laboratory investigation of metabolic pathways, energy balance mechanisms, and receptor signaling. This triple agonist peptide is expertly synthesized for scientific research applications and undergoes rigorous third-party laboratory testing to ensure research-grade quality and consistency.
Retatrutide Research Peptide Specifications:
| Unit Size | 6 or 12 or 16mg/vial |
| Unit Quantity | 1 vial |
| Purity (HPLC) | 99.7% |
| Sequence | Tyr-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-{α-Me-Leu}-Leu-Asp-Lys-{diacid-C20-gamma-Glu-(AEEA)-Lys}-Ala-Gln-{Aib}-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 (Sodium salt) |
| Molecular Formula | C221H342N46O68 |
| Molecular Weight | 4731.33 |
| CAS Number | 2381089-83-2 |
| Appearance | Lyophilized White Powder |
| Source | Chemical Synthesis |
| Storage Conditions | Lyophilized Retatrutide should be stored at -20°C. Reconstituted Retatrutide can be stored at 4°C for research applications. |
| Research Use Only | This research peptide is intended for laboratory research use only. Not for human consumption or therapeutic use. Please review our terms of service prior to ordering. |
Retatrutide is an investigational research peptide that functions as a triple agonist targeting GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon receptors. This multi-receptor approach distinguishes Retatrutide from single-pathway GLP-1 receptor agonists in laboratory studies.1
In preclinical research models, Retatrutide has been studied for its effects on metabolic signaling pathways, energy expenditure regulation, and glucose homeostasis mechanisms. The peptide's triple agonist activity allows researchers to investigate the synergistic interactions between GLP-1, GIP, and glucagon receptor pathways in controlled laboratory settings.2
Research studies examining Retatrutide focus on its molecular mechanisms in energy balance, lipid metabolism, and insulin signaling cascades. Laboratory investigations have explored how simultaneous activation of these three receptor systems influences metabolic processes at the cellular and systemic levels in animal models.3
The peptide's unique pharmacological profile makes it a valuable tool for obesity research, diabetes research, and metabolic syndrome studies. Researchers utilize Retatrutide to better understand multi-receptor agonism and its potential applications in metabolic disease research.
Scientific studies have documented Retatrutide's effects on body weight regulation, adipose tissue metabolism, hepatic lipid accumulation, and insulin sensitivity markers in laboratory animal models. These findings contribute to the broader understanding of metabolic receptor biology and therapeutic target identification.4
Important Research Notice: Nord-sci peptides undergo independent third-party laboratory testing to verify purity and identity. Certificate of Analysis (COA) documentation is provided with each research peptide to ensure quality standards for scientific research applications.
THIS PRODUCT IS INTENDED FOR LABORATORY RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION. NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE OR CONDITION.
Independent third-party laboratory testing results for Retatrutide research peptide purity and identity verification:
Download Retatrutide COA Lab Test Results
Purchasing research-grade Retatrutide requires sourcing from legitimate peptide suppliers that provide comprehensive quality documentation and third-party testing verification. Nordsci Peptides specializes in providing high-purity research peptides for qualified scientific research applications.
How to Source Retatrutide for Laboratory Research
Legitimate research peptide suppliers include specialized biochemical supply companies, licensed research chemical distributors, and verified peptide synthesis laboratories. Researchers should verify that suppliers provide Certificate of Analysis (COA) documentation, HPLC purity testing, and mass spectrometry verification for all research peptides including Retatrutide.
Retatrutide Research Peptide Pricing Considerations
The cost of research-grade Retatrutide varies based on purity level, quantity ordered, synthesis method, and supplier verification standards. Researchers should budget for laboratory-grade peptides that meet institutional research standards and include proper documentation for research compliance purposes.
Research Institution Procurement and Compliance
Research institutions and laboratories should follow institutional procurement guidelines when acquiring Retatrutide for research purposes. Proper documentation, storage protocols, and research oversight ensure compliance with institutional review board requirements and laboratory safety standards for peptide research.
IMPORTANT: Retatrutide is sold exclusively for in vitro research and laboratory applications. Not approved for human use, clinical applications, or therapeutic purposes. Researchers must comply with all applicable regulations governing peptide research in their jurisdiction.
Explore the mechanisms behind multi-receptor agonism and its applications in laboratory studies.
A comprehensive overview of GLP-1 receptor pathway research and emerging peptide therapeutics.
Laboratory protocols and guidelines for proper peptide storage and preparation.
