HCG (5000iu)
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HCG
Specification:
| Unit Size | 5000iu/vial |
| Unit Quantity | 1 vial |
| Purity (HPLC) | 99% |
| Sequence | Ala-Asp-Val-Gln-Asp-Cys-Pro-Glu-Cys-10-Thr-Leu-Gln-Asp-Pro-Phe-Ser-Gln-20-Pro-Gly-Ala-Pro-Ile-Leu-Gln-Cys-Met-Gly-30-Cys-Cys-Phe-Ser-Arg-Ala-Tyr-Pro-Thr-Pro-40-Leu-Arg-Ser-Lys-Lys-Thr-Met-Leu-Val-Gln-50-Lys-Asn-Val-Thr-Ser-Glu-Ser-Thr-Cys-Cys-60-Val-Ala-Lys-Ser-Thr-Asn-Arg-Val-Thr-Val-70-Met-Gly-Gly-Phe-Lys-Val-Glu-Asn-His-Thr-80-Ala-Cys-His-Cys-Ser-Thr-Cys-Tyr-Tyr-His-90-Lys-Ser |
| Molecular Formula | C1105H1770N318O336S26 |
| Molecular Weight | 25719.70 |
| CAS | 9002-61-3 |
| Appearance | lyophilized White to Yellowish Powder |
| Source | Chemical Synthesis |
| Storage | Store in an airtight container, protected from light at a temperature of 2-8°C. |
| Terms | The products we offer are intended for laboratory research use only. Please familiarize yourself with our terms of service prior to ordering. |
Human chorionic gonadotropin (HCG) is commonly detected in placental cells during pregnancy and can be synthesized as a human peptide. Its primary role is to support placental development. However, HCG has shown additional benefits according to research findings. It has been found to enhance male fertility by restoring testosterone production and treating infertility and low sperm count. Furthermore, HCG has been investigated for its potential in weight loss due to its ability to suppress the hunger hormone.
Numerous clinical trials and studies have explored the potential uses of HCG. In this section, we will highlight some noteworthy research findings.
HCG and its Potential in Addressing Hypogonadism HCG has long been considered as a potential treatment for hypogonadism, which involves low testosterone levels and infertility. This is attributed to HCG's ability to stimulate testosterone production and enhance sperm count, thereby potentially alleviating infertility.
A trial from 2019 found that using hCG to treat hypogonadal symptoms in men with a baseline testosterone level above 300 ng/dL could potentially be safe and effective without adverse events. Another study from 2018 demonstrated that hCG, whether administered alone or in combination with testosterone, could help men with hypogonadism maintain their fertility and potentially restore sperm production and count.
Potential to Improve Testosterone Deficiency According to the American Urology Association (AUA), doctors and clinicians should consider a total testosterone level below 300 ng/dL as the threshold for diagnosing hypogonadism and considering testosterone replacement therapy.
HCG acts as an analog of Luteinizing Hormone (LH), which is naturally produced in the pituitary gland and signals the testicles to produce more testosterone. By using HCG, it is possible to stimulate the body's natural up-regulation of testosterone production.
A small study from 2019 reviewed the clinical charts of 37 men with symptoms of low libido, low energy, erectile dysfunction, and insomnia, whose serum testosterone levels were above 300 ng/dL. These men received HCG as a potential treatment. HCG monotherapy demonstrated the potential to increase testosterone levels by up to 263 ng/dL (42.8%). While the study did not primarily focus on symptom improvement, the use of HCG to potentially raise testosterone levels was evident.
HCG and Sexual Dysfunction In a double-blind, placebo-controlled study conducted on forty-five individuals experiencing nonorganic sexual desire disorders, subjects were treated with either human chorionic gonadotropins or a placebo for one month. The study revealed that HCG potentially yielded better results compared to the placebo and improved a higher number of sexual parameters. This suggests that HCG could be a valuable option for sexological treatment of erectile failure and low sex drive.
The primary concern for peptide researchers today is product purity. Nord-sci guarantees our product purity by performing independent testing of our products and providing those certifications for our customers in our product descriptions.
THIS PRODUCT IS NOT INTENDED TO TREAT, CURE OR DIAGNOSE ANY CONDITION OR DISEASE AND IS NOT FOR HUMAN CONSUMPTION.
ALL PRODUCTS OFFERED ARE INTENDED FOR LABORATORY RESEARCH USE ONLY.
Mix each vial with: Bacteriostatic water. 1-2ml depending on desired dissolution.
Administration: 500-1000iu/ 2-3 times per week
HCG (Human Chorionic Gonadotropin) – Product Description
HCG (human chorionic gonadotropin) from NordSci is a high-purity, research-grade glycoprotein hormone preparation manufactured for controlled laboratory studies in reproductive endocrinology, hormone signaling, and pituitary–gonadal axis function. Each vial is rigorously tested by independent third-party laboratories to verify identity, potency, and purity for scientific research applications.
HCG Research Peptide Specifications:
| Unit Size | 5000 IU/vial |
| Unit Quantity | 1 vial |
| Purity (HPLC) | > 99% |
| Molecular Type | Dimeric glycoprotein hormone (α and β subunits) |
| Molecular Formula | C1105H1770N318O336S26 |
| Approximate Molecular Weight | ~36–40 kDa (glycosylated) |
| Appearance | Lyophilized white powder |
| Source | Highly purified human chorionic gonadotropin for research use |
| Storage Conditions | Store lyophilized HCG at -20°C in a dry environment. After reconstitution, store at 2–8°C for short-term use according to institutional guidelines. |
| Research Use Only | This material is supplied strictly for laboratory research use. Not for human consumption, clinical use, or veterinary applications. Review all NordSci terms of service prior to ordering. |
What Is HCG? Research Background and Mechanism
HCG is a placentally derived hormone that plays a central role in the maternal recognition of pregnancy and early gestational support. In physiological systems, HCG binds to the LH/hCG receptor expressed on gonadal cells, driving steroidogenesis and supporting corpus luteum function in females and testicular function in males.
Structurally, HCG is a heterodimeric glycoprotein composed of a common α subunit shared with other pituitary glycoproteins (TSH, FSH, and LH) and a β subunit that confers receptor specificity. This architecture makes HCG a key tool for interrogating LH/hCG receptor signaling, cAMP pathways, and downstream steroidogenic cascades in controlled endocrine research models.
In preclinical and clinical literature, HCG has been widely investigated in the context of fertility support, ovulation triggering, cryptorchidism, and male hypogonadotropic hypogonadism. Research models leverage HCG as a functional LH analog to study spermatogenesis induction, testicular growth, and gonadal hormone production under different endocrine conditions.
Beyond reproductive endpoints, HCG and related peptides have been explored for their potential immunomodulatory and anti-inflammatory properties, including effects on cytokine signaling and organ protection in systemic inflammatory models. These applications remain investigational and are best suited to well-controlled, hypothesis-driven laboratory designs.
Important Regulatory Note: Historic use of HCG in cosmetic or weight-loss protocols is not supported by robust clinical evidence, and HCG is not approved by regulatory agencies as a weight-loss agent. NordSci HCG is supplied exclusively for non-clinical research. It must not be repackaged, promoted, or used for any human weight-management application.
HCG Peptide Research: Key Laboratory Applications
1. Reproductive Endocrinology and Fertility Models
HCG is routinely referenced in the scientific literature for its ability to mimic luteinizing hormone activity at the gonadal level. In male endocrine research, HCG has been used to evaluate testicular growth, steroidogenesis, and the induction or restoration of spermatogenesis in hypogonadotropic hypogonadism models. In female systems, HCG is used to study final oocyte maturation, ovulation triggering, and luteal support in controlled ovarian stimulation paradigms.
2. Testicular Function and Hypogonadotropic Hypogonadism
Experimental frameworks investigating isolated hypogonadotropic hypogonadism frequently incorporate HCG, alone or in combination with human menopausal gonadotropin (HMG), to model testicular volume changes, sperm parameters, and endocrine recovery. These studies inform our understanding of how LH/hCG receptor activation impacts testicular architecture and future fertility potential.
3. Comparative Gonadotropin and GnRH Analogue Studies
Because HCG acts directly at the gonad, it serves as a useful comparator in research against upstream agents such as GnRH analogues or gonadorelin. Side-by-side models enable investigators to differentiate pituitary-mediated stimulation from direct testicular stimulation, characterize treatment timelines for spermatogenesis, and map distinct adverse-event profiles across hormone classes.
4. Endocrine Axis and Feedback Mechanisms
HCG is valuable for probing hypothalamic–pituitary–gonadal (HPG) axis feedback. By exogenously activating LH/hCG receptors, researchers can observe changes in endogenous gonadotropin release, sex-steroid levels, and feedback loops, generating data that support more refined models of endocrine regulation in both normal and pathologic states.
5. Immunomodulation and Inflammation Research
Emerging literature suggests that HCG and its related fragments may exert anti-inflammatory and cytoprotective actions in certain models of systemic inflammation and organ injury. In these settings, HCG is evaluated as a probe compound to better understand receptor-mediated immunomodulation, cytokine patterns, and potential synergy with other investigational agents.
Research Integrity Notice: All mechanistic and application descriptions above reflect findings from existing preclinical and clinical literature and are presented solely as context for laboratory research design. NordSci does not position HCG as a therapy, treatment, or medical intervention of any kind.
HCG Research Protocol and Reconstitution
Reconstitution Guidelines for Laboratory Use:
For in-house method development, investigators commonly reconstitute each 5000 IU vial of HCG with bacteriostatic water for injection to achieve a working stock appropriate for their model. The final IU/mL concentration, aliquoting strategy, and storage schedule should be defined by each laboratory’s internal SOPs, literature review, and oversight committee approvals.
Once reconstituted, HCG solutions should be handled aseptically, used within a defined stability window, and stored at 2–8°C unless internal validation supports alternative conditions. Freeze–thaw cycling should be minimized to protect structural integrity.
Protocol Disclaimer: The above information is provided as high-level research context only. NordSci does not prescribe dosing, frequency, routes of administration, or experimental endpoints. All in vivo work must follow IACUC guidance, institutional biosafety requirements, and applicable regulations.
HCG Certificate of Analysis (COA) – Lab Testing
Each lot of NordSci HCG is subjected to third-party testing for identity, potency, and purity using validated analytical methods. A Certificate of Analysis (COA) is available with each batch so research teams can document assay conditions, lot-specific results, and quality metrics within their own compliance frameworks.
Where to Buy HCG for Research Purposes
Researchers sourcing HCG for laboratory use should prioritize suppliers that specialize in research-only materials and maintain transparent quality systems. NordSci focuses exclusively on research-grade compounds, supported by COAs, HPLC purity verification, and consistent manufacturing standards designed to align with institutional expectations.
Procurement and Compliance Considerations
When onboarding HCG into a new program, research organizations should route acquisition through their standard procurement and compliance processes. Typical review steps include verification of research-use-only status, documentation of analytical testing, alignment with institutional animal care guidelines (for in vivo work), and confirmation that no clinical or over-the-counter claims are associated with the material.
Important: NordSci HCG is offered exclusively for in vitro and non-clinical research applications. It is not labeled, packaged, or intended for hormone replacement therapy, fertility treatment, bodybuilding, weight loss, or any other human or veterinary use.
Scientific References
- Yoo SK, et al. Human chorionic gonadotropin and related peptides: biology and emerging applications. Front Endocrinol. 2021.
- Wu H, Lustbader JW, et al. Structure of human chorionic gonadotropin at 2.6 Å resolution. Structure. 1994;2:545–558.
- Agarwal S, et al. Testosterone versus hCG in hypogonadotropic hypogonadism. J Clin Med. 2020.
- Amirzargar MA, et al. Comparison of rhFSH, hCG and HMG on sperm parameters after varicocelectomy: a randomized clinical trial. Int Braz J Urol. 2012.
- Zheng Y, et al. Pulsatile GnRH versus hCG/HMG for inducing spermatogenesis in congenital hypogonadotropic hypogonadism. Reprod Biol Endocrinol. 2025.
- Bosch B, et al. Human chorionic gonadotropin and weight loss: a double-blind, placebo-controlled trial. Br J Clin Pharmacol. 1990.
- Cleveland Clinic. Human Chorionic Gonadotropin Injection: Uses & Overview. Patient information monograph.
- FDA / regulatory summaries on HCG and weight-loss claims (various safety communications and practice reviews).
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
The products offered on this website are furnished for in vitro laboratory research use only. They are not medicines or drugs and have not been approved by the FDA to prevent, treat, or cure any medical condition, ailment, or disease. Any bodily introduction into humans or animals is strictly prohibited.