Epitalon is a synthetic peptide that mimics the naturally occurring peptide epithalamion found in the pineal gland. This peptide has shown promising results in reducing tumors in mice, according to various studies.
Epitalon is a synthetic peptide that has been found to increase the production of telomerase, a natural enzyme that aids in the replication of telomeres, which are the protective segments of our DNA. This enables the body to generate new cells and rejuvenate old ones. As people age, telomerase production decreases, which leads to a decline in cell replication and overall health, making it a major cause of aging.
Aside from its ability to increase telomerase production, Epitalon has also been found to regulate metabolism, enhance hypothalamus sensitivity, normalize anterior pituitary function, and regulate gonadotropins/melatonin levels in the body. It has been proven to be beneficial in several ways, including combating the symptoms of aging, improving mood, and acting as an antioxidant.
Studies have demonstrated the importance of telomerase and telomeres in slowing down the aging process, and Epitalon has been shown to increase telomerase production, resulting in stronger and longer telomeres. This suggests that Epitalon could play a critical role in delaying the aging process and potentially even extending life expectancy.
In one study, female C3H/He mice were given Epitalon five times a week for 6.5 months. The mice in both the experimental and control groups had spontaneous tumorigenesis in their ovaries and mammary glands. The study found that Epitalon reduced the number of metastases in the mice, and the experimental mice showed no evidence of metastases at all.
Another study examined the effects of Epitalon on spontaneous mammary tumors in female FVB/N HER-2/neu transgenic mice. The mice were treated with Epitalon for five consecutive days, and the study found that Epitalon reduced the size and number of tumors. Researchers theorized that the downregulation of the HER-2/neu gene is responsible for Epitalon's ability to inhibit the production of mammary tumors.
Epitalon is also considered a strong antioxidant that may be beneficial for longevity. Researchers examined the protective effects of Epitalon on age-damaged post-ovulatory oocytes in vitro in female mice. The results showed that Epitalon works as an antioxidant, reducing the number of reactive oxygen series present. The study also found that Epitalon regulates mitochondrial activity, leading to increased membrane potential, increased copy number of DNA, and decreased apoptosis of oocytes, ultimately delaying age-related damage.
The primary concern for peptide researchers today is product purity. Nord-sci guarantees our product purity by performing independent testing of our products and providing those certifications for our customers in our product descriptions.
THIS PRODUCT IS NOT INTENDED TO TREAT, CURE OR DIAGNOSE ANY CONDITION OR DISEASE AND IS NOT FOR HUMAN CONSUMPTION. ALL PRODUCTS OFFERED ARE INTENDED FOR LABORATORY RESEARCH USE ONLY.
All products are produced using lyophilization (freeze-drying), a preservation method that allows peptides to remain fully stable during shipping for approximately 3-4 months. Once a peptide has been reconstituted with bacteriostatic water, it must be refrigerated to maintain integrity. After reconstitution, peptides typically remain stable for up to 30 days when stored properly.
Lyophilization, also referred to as cryodesiccation, is a specialized dehydration process in which peptides are first frozen and then exposed to a low-pressure environment. This causes the water within the vial to transition directly from a solid to a vapor (sublimation), leaving behind a dry, crystalline white material known as a lyophilized peptide. In this powdered form, peptides may be safely stored at room temperature until they are ready to be reconstituted with bacteriostatic water.
After delivery, peptides should be protected from heat and light. If use is expected within the near future (whether days, weeks, or a few months) refrigerated storage below 4°C (39°F) is generally sufficient. Lyophilized peptides are commonly stable at room temperature for several weeks or longer, making short-term ambient storage acceptable when use is anticipated within that timeframe.
For extended storage, ranging from several months to multiple years, freezing is strongly recommended. Storage at -80°C (-112°F) offers optimal long-term stability and helps preserve peptide structure and quality over time.
For more detailed guidance on peptide handling and storage best practices, please refer to the resource below:
Epitalon (commonly referenced in the literature as Epithalon) is a synthetic tetrapeptide frequently used in controlled laboratory research focused on cellular aging pathways, circadian signaling, and telomere-associated biology. This peptide is often studied as a tool compound for investigating how short peptide sequences may interact with transcriptional regulation, oxidative stress models, and neuroendocrine signaling networks in preclinical settings.
Each vial of Epitalon is synthesized to research-grade standards and supported by third-party analytical testing to help laboratories maintain reproducible, protocol-driven experimental design. For teams building longevity and aging-related study pipelines, Epitalon is typically positioned as a mechanism-mapping peptide rather than a single-outcome compound, making it relevant across multiple preclinical endpoints.
Epitalon Research Peptide Specifications:
| Unit Size | 20 mg/vial |
| Unit Quantity | 1 vial |
| Purity (HPLC) | > 99% |
| Sequence | Ala-Glu-Asp-Gly (AEDG) |
| Appearance | Lyophilized White Powder |
| Source | Chemical Synthesis |
| Storage Conditions | Lyophilized Epitalon should be stored at −20 °C or below, protected from light and moisture. Reconstituted solutions should be stored at 2–8 °C and used promptly in accordance with institutional standards and protocol requirements. |
| Research Use Only | This peptide is supplied exclusively for laboratory research use. Not for human consumption, clinical use, or veterinary applications. |
Epitalon is a short peptide (four amino acids) originally developed and explored within aging and neuroendocrine research programs. In published studies, it has been investigated for potential relationships with pineal signaling, circadian rhythm markers, antioxidant defenses, and telomere-associated endpoints in cellular and animal models.
Mechanistically, Epitalon is most frequently discussed as a peptide that may influence gene expression patterns relevant to cellular stress responses and replication limits. In certain in vitro models, researchers have examined whether Epitalon exposure affects telomerase activity and telomere length dynamics, a line of inquiry that continues to inform study design in longevity-oriented research pipelines.
In practice, research teams often evaluate Epitalon alongside adjacent “systems” peptides depending on the study’s objective. For example, labs exploring tissue repair endpoints may pair it conceptually with BPC 157 or Thymosin Beta 4 in broader program mapping, while teams building metabolic longevity frameworks may cross-reference molecules like NAD or MOTS-C to benchmark mitochondrial and cellular-energy endpoints across separate experiments.
Important Research Notice: Nordsci peptides are supported by independent third-party analytical testing to validate identity and purity via HPLC and mass spectrometry. A Certificate of Analysis (COA) is available for each lot to support documentation, QC review, and internal audit workflows.
THIS PRODUCT IS INTENDED FOR LABORATORY RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION. NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE OR CONDITION.
One of the most frequently cited research angles for Epitalon is its use in studies investigating telomere-associated endpoints. In vitro experiments have evaluated whether Epitalon exposure correlates with changes in telomerase activity and telomere length maintenance in human somatic cells. These models typically measure replication capacity, senescence markers, and downstream transcriptional signals that align with cellular aging frameworks.
For labs designing multi-cohort experiments, Epitalon can serve as a controlled variable to test whether short peptide signaling shifts the pace of senescence markers, independent of more complex growth-factor signaling. This makes it a pragmatic research probe for teams focused on hypothesis validation and mechanism isolation.
Epitalon is often discussed in relation to pineal biology and circadian rhythm research. Preclinical studies have explored whether peptide exposure influences circadian-regulated outputs, oxidative stress resilience, and neuroendocrine signaling patterns. In these contexts, researchers may track biomarkers tied to sleep-wake regulation, hormonal rhythms, and time-dependent gene expression.
Because circadian pathways can influence metabolic and immune function in experimental models, Epitalon is sometimes incorporated into broader study maps that also track cognitive performance or stress resilience markers. When labs need a comparator for cognitive performance frameworks, peptides such as Semax and Selank are frequently referenced as separate-category tools for neurocognitive endpoints.
If your pipeline is expanding into telomere biology, oxidative stress, or circadian signaling, consolidating sourcing and documentation can reduce downstream friction. Standardize your inventory with research-grade peptides supported by COAs and consistent lot tracking.
Shop all peptidesAcross multiple research programs, Epitalon has been evaluated in oxidative stress models where investigators monitor reactive oxygen species (ROS) signaling, antioxidant enzyme activity, and gene expression changes associated with cellular protection pathways. These studies often include readouts such as lipid peroxidation, DNA damage markers, mitochondrial function metrics, and inflammatory signaling profiles.
Epitalon’s role here is typically exploratory: it helps labs determine whether a short peptide signal can shift stress-response thresholds or influence transcriptional programs relevant to cellular aging. For teams building high-throughput screens, Epitalon can be integrated into a peptide panel to identify signal directionality before committing to longer in vivo study timelines.
In modern peptide research, Epitalon is rarely studied in isolation from the broader aging stack ecosystem. Instead, it is often positioned as a mechanism-focused compound, while other peptides are selected to isolate additional domains like repair, recovery, metabolic signaling, and body composition. For example, protocols centered on tissue recovery signaling may evaluate GHK-CU or repair-aligned peptides in adjacent experiments, while body composition research may focus on peptides like AOD-9604 or Frag 176-191.
This separation-by-endpoint approach reduces confounding variables and creates cleaner interpretation across datasets, especially when multiple teams share the same animal facility, assay stack, or reporting standards.
Reconstitution Guidelines for Laboratory Use:
For laboratory use, each 20 mg vial of Epitalon is typically reconstituted with bacteriostatic water or another suitable sterile diluent to achieve the desired stock concentration. Concentration, route, and exposure schedules should be determined by the research team based on study design, assay requirements, species considerations, and institutional approvals.
Protocol Design Considerations: Published studies vary widely in exposure duration and endpoint selection (cell culture vs. animal models). Research teams should anchor protocol design to peer-reviewed literature, internal SOPs, and ethics/IACUC approvals, ensuring all handling and documentation aligns with institutional compliance requirements.
Note: The information above is provided as a high-level research reference only. All experimental use must be conducted by qualified personnel in appropriately equipped facilities, following applicable regulations and institutional policies.
Each lot of Epitalon is supported by a Certificate of Analysis documenting peptide identity and purity. COA documentation supports lab recordkeeping, validation checklists, and standardized procurement workflows where analytical transparency is non-negotiable.
When sourcing Epitalon for institutional research, the operational priority is consistency: lot-to-lot reliability, transparent analytical documentation, and clear labeling aligned with research-only procurement standards. Nordsci Peptides focuses on supplying high-purity peptides with traceable QA, giving research teams a scalable procurement path as study volume grows.
How to Source Epitalon for Laboratory Research
Validate that the supplier provides COAs, batch identifiers, and purity verification (e.g., HPLC and mass spectrometry). This documentation protects the integrity of downstream datasets, simplifies internal audits, and supports cross-team reproducibility.
Epitalon Research Peptide Pricing Considerations
Pricing is typically driven by synthesis complexity, purity targets, and the breadth of analytical testing performed. In many lab environments, the total cost calculation includes documentation value and supply continuity, not just the per-milligram line item.
IMPORTANT: Epitalon is sold exclusively for in vitro and preclinical research applications. It is not approved for human use or any therapeutic purpose. Researchers are responsible for complying with all applicable regulations and institutional policies governing peptide research in their jurisdiction.
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