PE-22-28 (8mg) is a synthetic peptide fragment supplied exclusively for controlled laboratory research. It is not intended for human or animal consumption or for diagnostic, therapeutic, veterinary, food, cosmetic, or dietary-supplement use.
PE-22-28 is derived from the spadin peptide sequence and is studied in experimental systems involving TREK-1 potassium-channel activity, membrane signaling, and peptide-target interactions. Its abbreviated sequence allows researchers to examine specific molecular interactions under defined laboratory conditions.
Each vial contains 8mg of lyophilized peptide material. Consult the lot-specific Certificate of Analysis for available information regarding compound identity, analytical testing, and purity.
The primary concern for peptide researchers is access to clear, batch-specific analytical documentation. Nordsci provides applicable testing records and Certificates of Analysis through its online COA Library.
The primary concern for peptide researchers today is product purity. Nord-Sci guarantees our product purity by performing independent testing and providing certifications for our customers in the product descriptions.
THIS PRODUCT IS NOT INTENDED TO TREAT, CURE, OR DIAGNOSE ANY CONDITION OR DISEASE AND IS NOT FOR HUMAN CONSUMPTION. ALL PRODUCTS OFFERED ARE INTENDED FOR LABORATORY RESEARCH USE ONLY.
All products are produced using lyophilization (freeze-drying), a preservation method that allows peptides to remain fully stable during shipping for approximately 3-4 months. Once a peptide has been reconstituted with bacteriostatic water, it must be refrigerated to maintain integrity. After reconstitution, peptides typically remain stable for up to 30 days when stored properly.
Lyophilization, also referred to as cryodesiccation, is a specialized dehydration process in which peptides are first frozen and then exposed to a low-pressure environment. This causes the water within the vial to transition directly from a solid to a vapor (sublimation), leaving behind a dry, crystalline white material known as a lyophilized peptide. In this powdered form, peptides may be safely stored at room temperature until they are ready to be reconstituted with bacteriostatic water.
After delivery, peptides should be protected from heat and light. If use is expected within the near future (whether days, weeks, or a few months) refrigerated storage below 4°C (39°F) is generally sufficient. Lyophilized peptides are commonly stable at room temperature for several weeks or longer, making short-term ambient storage acceptable when use is anticipated within that timeframe.
For extended storage, ranging from several months to multiple years, freezing is strongly recommended. Storage at -80°C (-112°F) offers optimal long-term stability and helps preserve peptide structure and quality over time.
For more detailed guidance on peptide handling and storage best practices, please refer to the resource below:
PE-22-28 is a synthetic peptide fragment associated with the spadin peptide sequence. Spadin originates from a sortilin-derived propeptide and has been examined in laboratory research involving TREK-1, a two-pore-domain potassium channel associated with membrane conductance and neuronal excitability.
PE-22-28 allows researchers to investigate a shortened peptide sequence in controlled experimental models. Research involving this material may include analytical characterization, peptide-channel interaction studies, electrophysiological assays, and evaluation of downstream signaling observations.
General background concerning neurotransmitter systems is available through NCBI’s overview of neurotransmitter systems.
PE-22-28 (8mg) – Research Specifications:
| Compound | PE-22-28 |
| Quantity | 8mg per vial |
| Compound Type | Synthetic spadin-derived peptide fragment |
| Purity / Identity | Refer to the lot-specific Certificate of Analysis |
| Appearance | Lyophilized peptide material |
| Storage Conditions | Store sealed and protected from heat, light, and moisture; follow the product label or lot-specific documentation |
| Testing Documentation | Available analytical information is provided through the COA Library |
| Research Use Only | For controlled laboratory research only; not for human or animal consumption |
PE-22-28 is a shortened peptide fragment derived from spadin, which is associated with the sortilin propeptide. Spadin-derived sequences have been examined in laboratory systems involving TREK-1 channel activity and related membrane-signaling mechanisms.
TREK-1 belongs to the two-pore-domain potassium-channel family. These channels are studied for their role in potassium conductance, membrane potential, cellular excitability, and responses to experimental conditions.
PE-22-28 provides researchers with a defined fragment for investigating peptide structure, target interaction, and channel-response characteristics. Research involving PE-22-28 should remain limited to appropriately designed laboratory models and qualified research environments.
Background information concerning TREK-1 and spadin-related research is available through Frontiers in Pharmacology.
Important Research Notice: Nordsci research materials are accompanied by applicable lot-specific analytical documentation. Researchers should review the Certificate of Analysis before incorporating a material into an experimental workflow.
THIS PRODUCT IS INTENDED FOR LABORATORY RESEARCH USE ONLY. NOT FOR HUMAN OR ANIMAL CONSUMPTION. NOT INTENDED FOR DIAGNOSTIC, THERAPEUTIC, VETERINARY, FOOD, COSMETIC, OR DIETARY-SUPPLEMENT USE.
PE-22-28 may be incorporated into controlled assays examining TREK-1 channel activity, membrane conductance, and experimentally observed channel responses.
Researchers may use defined laboratory models to examine how potassium-channel activity relates to membrane signaling and cellular communication. Findings are specific to the experimental system and should not be interpreted as evidence of a clinical or therapeutic effect.
PE-22-28 may be evaluated in peptide-target binding, structure-activity, and molecular-interaction studies. General background on receptor and signaling research is available through Nature Reviews Drug Discovery.
Controlled laboratory models may use PE-22-28 to examine relationships among membrane channels, cellular excitability, and signal transmission. Experimental results can vary according to assay design, model selection, material handling, and analytical methodology.
PE-22-28 (8mg) should be handled by qualified laboratory personnel using procedures appropriate for research-grade peptide materials. Researchers should review the product label and lot-specific Certificate of Analysis before use.
Experimental controls should account for factors such as peptide stability, material concentration, assay conditions, target expression, channel behavior, and analytical sensitivity.
Protocol Design Considerations: Results may vary across in vitro, analytical, and other nonclinical research models. Appropriate controls, validated instrumentation, documented handling procedures, and reproducible methodologies are necessary for reliable interpretation.
No dosing, administration, human-use, animal-use, or therapeutic-application guidance is provided.
Note: This information is supplied solely as a technical reference for qualified laboratory researchers.
Lot-specific analytical documentation is available for PE-22-28 supplied by Nordsci Peptides. The applicable Certificate of Analysis should be consulted for reported identity, purity, test methods, and other batch-specific information.
The COA supports material traceability and laboratory recordkeeping. It does not establish that the compound is safe, effective, approved, or suitable for human, animal, diagnostic, or therapeutic use.
Nordsci Peptides supplies PE-22-28 (8mg) exclusively as a laboratory research material. Qualified laboratories can review available product specifications and batch-specific analytical documentation before procurement.
IMPORTANT: PE-22-28 (8mg) is not a drug, food, cosmetic, or dietary supplement. It is not approved for human or veterinary use and must not be used for consumption, diagnosis, treatment, prevention, or any other clinical application. Purchasers are responsible for compliance with applicable laws, institutional policies, and laboratory requirements.
